Posts tagged as “Alzheimer’s Risk”

Women with family histories of late-onset AD have higher amyloid burdens the closer they are to parental age of onset.
Parental age of onset might be used to prescreen women for AD trials, reducing the number of screen failures.
In dominantly inherited AD cohorts, researchers have found a strong link between amyloid accumulation and parental EYO.
Genotype did not modify the effect of parental EYO in ACS, but ApoE4 carriers in WRAP did accumulate plaques faster the closer they were to parental EYO.
The mean participant age across the three cohorts in this study was 62, with the parental EYO averaging 74.