“Elevated cerebrospinal fluid (CSF) neurofilament light levels (NfL) are associated with an increased risk of mild cognitive impairment (MCI), indicate findings from a population-based study. Among 648 individuals without cognitive impairment, those in the highest quartile for CSF NfL had a significant 2.9-fold increased risk for developing MCI, compared with those in the lowest quartile, after taking into account age, sex, level of education and comorbidities. The risk increased further still to 3.1-fold after additional adjustment for apolipoprotein E (APOE) genotype.”
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CSF neurofilament light a ‘preferred’ biomarker for MCI progression
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