DIAN and ADNI Data Say Familial and Sporadic AD Converge

In other words, is dominantly inherited AD the same or different from sporadic AD? The findings to date indicate that despite having different causes, familial and sporadic AD on the whole share the same pathophysiology and progression. The findings suggest that treatments developed for familial AD would work for sporadic. Both diseases are marked by altered Aβ42 homeostasis, but autosomal-dominant disease is caused by both an overproduction and impaired clearance of the peptide, while sporadic is believed to be due to impaired clearancePeople with a familial AD mutation experience more aggressive amyloidosis than do people with sporadic AD. ADNI participants had more years of education than DIAN participants on average, and they were all from North America whereas DIAN is worldwide.
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