A new understanding of tau could refine Alzheimer’s approaches

Scientists have hypothesized that dying brain cells break apart and release proteins, including tau, which then form the tangles that are a hallmark of the disease. New research from Washington University in St. Louis shows, however, that tau secretion is actually an active process, not a byproduct of cell death—findings that could refine tau-targeting treatments for Alzheimer’s. “Our results showing that tau production is increased suggest that we might want to target tau production therapeutically.”
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