Although certain genetic variants increase the risk of Alzheimer’s disease (AD), age is the strongest known risk factor. But the way in which molecular processes of ageing predispose people to AD, or become impaired in AD remains a mystery. Changes to the way H4K16ac, a key epigenetic marker, is modified along the genome in disease versus normal ageing brains may signify places for future drug development. The finding indicates that certain normal ageing changes in the epigenome may actually protect against AD and when these goes awry, a person may become predisposed to AD.
Publication: Dysregulation of the epigenetic landscape of normal aging in Alzheimer’s disease.
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Epigenetic Landscape’ is Protective in Normal Ageing, Impaired in Alzheimer’s Disease, Says Study
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