H4K16ac is a key modification in human health because it regulates cellular responses to stress and DNA damage. In addition, the team discovered an association between the location of H4K16ac changes and genetic variants identified in prior AD genome-wide association studies. “We found that while normal aging leads to H4K16ac enrichment, AD entails dramatic losses of H4K16ac in the proximity of genes linked to aging and AD. This finding indicates that certain normal aging changes in the epigenome may actually protect against AD and when these go awry, a person may become predisposed to AD. “Our results establish the basis for an epigenetic link between aging and AD,” the authors concluded.
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Alzheimer’s: Epigenetic Dysregulation May Be Key to Onset
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